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KMID : 0043320050280121328
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1328 ~ p.1332
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[β]-Secretase (BACE1) Inhibitors from Pomegranate (Punica granatum) Husk
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Kwak Hye-Min
Jeon So-Young
Sohng Bang-Ho
Kim Jong-Guk
Lee Jin-Man
Lee Kyung-Bok
Jeong Hyun-Hee
Hur Jong-Moon
Kang Young-Hwa
Song Kyung-Sik
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Abstract
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In the course of screening for anti-dementia agents from natural products, two -secretase (BACE1) inhibitors were isolated from the husk of pomegranate (Punica granatum) by activity-guided purification. They were identified as ellagic acid and punicalagin with values of 3.9 and 4.1 M and Ki values of 2.4and 5.9 M, respectively. The compounds were non-competitive inhibitors with a substrate in the Dixon plot. Ellagic acid and punicalagin were less inhibitory to -secretase (TACE) and other serine proteases such as chymotrypsin, trypsin, and elastase, thus indicating that they were relatively specific inhibitors of BACE1.
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KEYWORD
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Pomegranate (Punica granatum), Ellagic acid, Punicalagin, Alzheimer’s disease
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